In biology, the term refers to stabilized cell-cell junctions or synaptic connections that have completed their developmental phase.

: In neurons, maturation is marked by a transition from high-density immature synapses to sparser, more stable mature contacts that provide robust circuit connectivity.

: While immature contacts may only require broad marketing, mature contacts benefit from direct interaction. For example, automated marketing via SMS or WhatsApp can see conversion increases of up to 21% once a lead has matured.

: Mature contacts in heart tissue (cardiomyocytes) are 39–44 times more effective at conducting electrical excitation than immature ones.