The story follows a new group of survivors—including a biker gang, midget wrestling brothers, a used car salesman, and an opportunistic hobo—who must band together with the remaining bar survivors to fight off a fresh onslaught of creatures.

picks up the morning after the bloodbath at the bar in the first film. The flesh-eating, sexually aggressive monsters have followed the survivors to a nearby small town in the middle of nowhere.

: The film introduces bizarre new characters with freeze-frame "score cards," such as Thunder and Lightning (the wrestlers) and a biker gang featuring Biker Queen and Splat Girl .

: Maintaining the series' pitch-black humor, the film subverts horror tropes by killing off "heroic" characters unexpectedly and focusing on the most depraved survival instincts.