[s4e16] House's Head (part 2) -

: The recovered memory reveals that House, too drunk to drive, called Wilson for a ride; Amber arrived instead. They were on the bus together when the accident occurred. The Medical and Moral Failure

: The finale fundamentally alters the series' core relationship. Wilson is left alone, finding a final note from Amber, while House awakens from a coma to face the wreckage of his friendship. [S4E16] House's Head (Part 2)

For more detailed production history and award information, you can visit the House's Head Wikipedia page and the Wilson's Heart Wikipedia page . : The recovered memory reveals that House, too

In the second part, "Wilson's Heart," the team discovers Amber is suffering from multisystem organ failure. Wilson is left alone, finding a final note

: The episode concludes with Thirteen testing positive for Huntington’s disease, echoing the theme that life is often "unfair" and beyond a doctor's control.

: House deduces that Amber was taking amantadine for the flu. The crash caused acute kidney failure, preventing her body from processing the drug and resulting in lethal amantadine poisoning.

The finale begins with House suffering from retrograde amnesia following a bus accident. Convinced he witnessed a life-threatening symptom in a fellow passenger before the crash, House undergoes increasingly dangerous procedures—including hypnosis and deep brain stimulation—to retrieve the lost memory.