Picking up immediately after the intense hospital blackout from the Season 1 finale, the episode centers on the immediate medical and personal fallout for the staff at Sorolla Hospital.
" Changes " is the title of the premiere episode of Season 2 for the Spanish medical drama series (original title: Respira ), which aired on November 2, 2025 . [S2E1] Changes
: The chaos begins with Pilar ordering Biel to perform a high-stakes operation on a bleeding Jesica. While Jesica initially appears to recover, she later experiences severe hallucinations—a side effect of toxins reaching her brain—and tragically cuts herself open in a state of distress. Picking up immediately after the intense hospital blackout
: The conflict between experts like Dr. Murillo, who have grown indifferent to patient opinions, and managers who prioritize administrative "revamping" over staff well-being. While Jesica initially appears to recover, she later
: Investigates medical misconduct after a patient reports Dr. Murillo for forced labor. Critical Analysis
: Faces professional confusion as he is asked to juggle a double residency in oncology and general surgery while dealing with Jesica's erratic behavior.
The following analysis recaps the episode's major plot points and thematic developments.