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: High-dose estrogen regimens used in earlier decades were linked to an increased risk of cardiovascular death , though modern, lower-dose regimens aim to mitigate these risks.

Studies have examined how MtF individuals are perceived and how they navigate social binaries: rate shemales

: A long-term study at a university gender clinic found that total mortality in MtF transsexuals was 51% higher than in the general population, largely attributed to increased rates of suicide, AIDS, and cardiovascular disease. : High-dose estrogen regimens used in earlier decades