Search for "Splenic B-cell Lymphoma review."
A provisional category for cases that do not meet the strict criteria for SMZL or SDRPL. 3. Diagnostic Approach
Search for "Splenic Marginal Zone Lymphoma guidelines."
Treatment is indicated only for symptomatic patients (progressive cytopenia or painful splenomegaly).
is a frequent cytogenetic abnormality found in approximately 40% of SMZL cases. 4. Clinical Presentation and Complications
Splenic lymphomas represent a heterogeneous group of rare B-cell neoplasms primarily involving the spleen, bone marrow, and often the peripheral blood. The most common subtype is Splenic Marginal Zone Lymphoma (SMZL). This paper reviews the clinical presentation, diagnostic criteria (histology and immunophenotype), and evolving therapeutic strategies for these malignancies. 1. Introduction