Diseases - Mr Validity May 2026

MR uses genetic variants as "natural experiments" to determine if an exposure (like high blood pressure) truly causes a disease (like stroke), rather than just being associated with it. ⚖️ The Three Pillars of MR Validity

: A Bayesian meta-regression tool used by the Global Burden of Disease Study to ensure consistency between disease incidence, prevalence, and mortality data. Diseases - Mr Validity

: There are no common causes (confounders) shared between the genetic variants and the outcome. MR uses genetic variants as "natural experiments" to