The human "immunotype" is shaped by a complex interplay of heritable and non-heritable factors:
Studies using high-dimensional flow cytometry and single-cell sequencing show that "healthy" ranges are broader than traditionally thought: Determining the expected variability of immune ...
Heritability plays a more pronounced role in T cell populations compared to B cells , which are more susceptible to environmental cues. Specific genetic variants (ccQTLs) have been identified that regulate leukocyte counts and contribute to disease susceptibility. Expected Variation in Healthy Adults The human "immunotype" is shaped by a complex
B cell subsets and certain antibodies like IgG1 show significant fluctuations based on the time of year. Determining the expected variability of immune ...
Factors such as cohabitation, smoking, and cytomegalovirus (CMV) infection significantly alter immune composition. CMV alone can affect over 50% of immune parameters in an individual.