C4.zip -

The C4 ZipTip is most commonly used in the workflow for (Matrix-Assisted Laser Desorption/Ionization Time-of-Flight).

A C4 ZipTip is a standard pipette tip containing a microscopic bed of resin fixed at its distal end. Unlike C18 resins, which are used for smaller peptides, the C4 resin is optimized for larger, more hydrophobic molecules like proteins and large polypeptides. Primary Uses in Research Researchers use these tools for two main reasons: c4.zip

: Contaminants are washed away with a dilute acid, such as trifluoroacetic acid (TFA) . The C4 ZipTip is most commonly used in

: Best for proteins > 10 kDa and highly hydrophobic peptides. which are used for smaller peptides

This technology has been instrumental in recent studies, including identifying SARS-CoV-2 protease cleavage sites and characterizing human cannabinoid receptors.