The journey takes the trio on a chaotic road trip across the country, featuring:

Realizing they need inside information on Poison Ivy’s whereabouts, and Nightwing track down her best friend, Harley Quinn , who has been living a quiet life since being paroled. Harley is initially reluctant to rejoin the world of masks and capes, but after a tense and somewhat bizarre interaction with Nightwing, she agrees to help the duo find her "bestie".

The world faces a global threat when and Jason Woodrue (the Floronic Man) team up to steal experimental data from S.T.A.R. Labs . Their plan is to release a mutagenic virus that will turn all animal life on Earth into plant-human hybrids to save the planet from environmental destruction.