Atopy | 2026 |

: Systemic immune priming eventually leads to upper and lower airway inflammation. 3. Key Management Strategies

: Often the first sign in infancy, caused by skin barrier defects (e.g., filaggrin mutations) that allow for epicutaneous allergen sensitization. : Systemic immune priming eventually leads to upper

Atopy is a genetic predisposition toward developing exaggerated IgE-mediated immune responses to common environmental allergens. Clinically, it manifests as a triad of conditions—, allergic rhinitis (hay fever) , and allergic asthma —often appearing sequentially in a pattern known as the "atopic march". 1. Pathophysiology and Mechanism caused by skin barrier defects (e.g.