While an abnormal ratio can sometimes indicate a serious condition, it is often caused by non-cancerous factors. Common Causes of an Abnormal Ratio
A rare condition where misfolded light chains build up in organs like the heart or kidneys. Typical Next Steps Abnormal Serum Light Chain Ratio
Because the kidneys filter these proteins out of your blood, chronic kidney disease can lead to higher levels and slightly altered ratios. While an abnormal ratio can sometimes indicate a
Conditions like rheumatoid arthritis or recent viral infections can temporarily increase light chain production. skewing the ratio.
An indicates that the balance between two types of proteins— kappa and lambda free light chains—is outside the standard range of roughly 0.26 to 1.65 . These proteins are produced by plasma cells to help your immune system fight infections.
Conditions like multiple myeloma or MGUS (Monoclonal Gammopathy of Undetermined Significance) can cause one type of light chain to be overproduced, skewing the ratio.