According to recent studies from the NIH HIV Reagent Program and the American Society for Microbiology , tazarotene acid is being investigated for the following:
While "21367.rar" might occasionally appear as a generic archive filename in legacy datasets, the number is most prominently associated with this specific biochemical reagent in scientific literature as of early 2026 [14, 21]. 21367.rar
Tazarotene acid is the active carboxylic acid metabolite of the prodrug tazarotene [21]. It functions as a selective retinoid X receptor (RXR) and retinoic acid receptor (RAR) agonist, specifically targeting and RAR- [14]. Key Research Applications According to recent studies from the NIH HIV
Third-generation retinoid / Retinoic Acid Receptor (RAR) Agonist [14] Enhances NK degranulation and effector function [14] Research Focus specifically targeting and RAR- [14].
: It functions by increasing the expression of CD16 on NK cells, which improves their ability to recognize and destroy infected targets [14]. Technical Specifications Catalog Number 21367 (Commonly via Cayman Chemical) [21] Class
: It has been identified as a compound capable of sensitizing latently infected HIV cells to apoptosis [14, 21].
: Research indicates it significantly enhances Natural Killer (NK) cell natural cytotoxicity and antibody-dependent cellular cytotoxicity (ADCC) against HIV-infected CD4 T cells [14, 21].